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This study aims to determine the most effective dose in reducing fever in white rats induced by DPT-HB vaccine. The research method is an experimental laboratory using the method without heating for the manufacture of syrup. The results of initial temperature measurements in all treatment groups of white rats which is the normal temperature of the test animals before the DPT-HB vaccine is obtained ranged between 35.10C-37.10C. after 2 hours of DPT-HB vaccine injection, the body temperature of the white rats was measured again and the results obtained were 36,930C-38,430C. an increase in body temperature after 2 hours of injecting this vaccine compared to the results of measuring body temperature before the vaccine is injected is a sign that the test animal has experienced a fever. The negative control group which was given syrup without extract orally, showed the body temperature of the test animals had decreased as the temperature after injecting the vaccine. On the administration of alvocate leaf flavonoid syrup, the dose ¼ showed a decrease of 0.40C. For the administration of dosage flavonoid syrup extract dosage 1, it showed that the body temperature of the test animals had a temperature drop of 1,330C. And administration of Alvocado leaf flavonoid syrup extract dose 2, showed that the body temperature of the test animals had a temperature drop of 0.6 . While the administration of Alvocado leaf flavonoid extract syrup dose 3, showed that the body temperature of the test animals experienced a temperature increase of -0.2 . From the results obtained, it can be concluded that the most effective dose of antipyretic syrup of alvocado leaf flavonoid extract is dose 1.
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